The Cytokine Society recognizes the following Outstanding Abstracts to be presented at Cytokines 2025: the 13th Annual Meeting of the International Cytokine and Interferon Society, November 2 – 5, 2025 at the Westin Hotel in Seattle, Washington, USA
Sophie Aicher
Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. Vaccine and Infectious Disease Organization, University of Saskatchewan, Canada
Abstract: Characterization of innate immune features and mechanisms of disease tolerance in white-tailed deer infected with SARS-CoV-2
Trisha Barnard
Department of Medicine, Stanford University School of Medicine, United States
Abstract: Time-resolved single-cell analysis of antiviral immunity
Abigail Cozart
Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, United States
Abstract: Altered TNF-α Response in Down Syndrome
XueFeng Fei
Department of Laboratory Medicine, Ruijin Hospital, College of Health Sciences and Technology, Shanghai Jiao Tong University School of Medicine, China
Abstract: Nuclear SUMOylation promotes cytosolic inflammasome activity
Jeff Ge (Joan Oefner Travel Grant Recipient for highest scoring abstract)
Department of Microbiology and Immunology, The Doherty Institute for Infection and Immunity, University of Melbourne, Australia
Abstract: IL-4 PROMOTES THE GENERATION OF LIVER-RESIDENT T CELL MEMORY
Adam Hage
Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, United States
Abstract: The transcription factor HNF4α defines antiviral action by shaping the innate immune chromatin landscape
Leonardo Huang
Children’s Hospital of Philadelphia, United States
Abstract: A CDC42 C-terminal mutation, linked to severe hyperinflammation in humans, exhibits no distinct phenotype in murine models
Weidong Jing
University of Cambridge, United Kingdom
Abstract: Synergistic Activation of NLRC4 and NLRP3 Inflammasomes in Autoinflammation Driven by NLRC4 Gain-of-Function Mutations
Pooja Kaur
Imperial College London, United Kingdom
Abstract: Tumour-targeted TNFα reduces systemic toxicity and drives complete remissions in immunologically cold murine tumours.
Yağmur Keser
University of Florida, Gainesville, United States
Abstract: Basal IFNλ2/3 expression regulates tight junction formation in human epithelial cells
Yang Li
Division of Rheumatology & Clinical Immunology, Department of Medicine, University of Pittsburgh, United States
Abstract: Arid5a is a novel feed-forward activator and biomarker of TNF signaling in rheumatoid arthritis
Kylie March
University of Wisconsin-Madison, United States
Abstract: The Role of FFAR3 in Tuft Cell Dependent Responses in the Biliary Tree
Christy Montano
University of California, Santa Cruz, United States
Abstract: CRISPRi Screen Identifies a Novel Growth Suppressor lncRNA in Human Monocytes
Andrea Ordonez
University of Colorado, Boulder, United States
Abstract: Alternative isoform expression tunes IL-18 signaling in mammalian immunity
Elisa Saccon
Center for Hematology and Regenerative Medicine, Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden
Abstract: A novel ISG15 missense variant identified in a patient with susceptibility to severe viral infections
Natalia Sampaio
Hudson Institute of Medical Research, Clayton, United States
Abstract: MDA5 guards against infection by surveying cellular RNA homeostasis
Elisha Segrist
National Institute for General Medical Sciences, United States
Abstract: Investigation of interferon lambda’s role in immunoregulation and bacterial infection in the female reproductive tract
Hamna Shahnawaz
Columbia University, New York, United States
Abstract: Compartmentalization of the human interferome for tissue-specific immunity
Zhengzheng Shi
Cedars-Sinai Medical Center, Los Angeles, United States
Abstract: IL-27R Signaling Controls Protective versus Pathogenic T cell Immune Responses in Hepatocellular Carcinoma
So-Jin Sim
College of Pharmacy, Kangwon National University, Chuncheon, Korea
Abstract: Macrophage Endotoxin Tolerance, Regulated by AOAH, Attenuates Hepatic Inflammation and Fibrosis in MASH.
Soumba Traore
University of Minnesota Medical School, Minneapolis, United States
Abstract: Zika Virus disrupts LIF–STAT3 signaling and alters placental trophoblast function
Yaxuan Yang
Department of Immunology, Integrative Systems Biology PhD program, Center for Systems Immunology, University of Pittsburgh, United States
Abstract: IFN-β-mediated reprogramming of IL-6 driven STAT3 specificity and inflammatory function
Clara Young
University of California, San Diego, United States
Abstract: Interrogating Host-Specific Effector-Triggered Immune (ETI) Sensing of Viral Infection Across Diverse Mammalian Species.
Hongyu Zheng
Centre for innate immunity and infectious diseases, Hudson institute of medical research, Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology, University of Melbourne, Australia
Abstract: Identifying a novel inflammatory disorder caused by mutation in coatomer complex I
Pascale Zwicky
Weizmann Institute of Science, Rehovot, Israel
Abstract: A tumor-associated macrophage-targeted immunocytokine leveraging T and NK cell synergy for potent cancer immunotherapy